Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (3): 132-133.doi: 10.3969/j.issn.1004-616x.2004.03.002

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Study on the Antioxdation Effects of Vitamin E or/and Lipioc Acid on Mice Injuries Caused by Phosgene

ZHANG Xiao-di，HAI Chun-xu，LI Wen-li，et al   

  1. Department of Toxicology,Faculty of Preventive Medicine,the Fourth Military Medical University,Xi'an 710032, China
  • Received:2003-12-08 Revised:2004-02-16 Online:2004-05-30 Published:2004-05-30
  • Contact: HAI Chun-xu

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Abstract: BACKGROUND ＆ AIM: To study the antioxidation effcts of Vitamin E or/and lipioc acid on mice injuries caused by phosgene. MATERIAL AND METHODS:50 mice with acute injury induced by phosgene were randomly divided into 5 groups of control, poisoning,Vitamin E,lipioc acid,Vitamin E adding lipioc acid.The WBC and PLT were analyzed with auto－analysis meter,and MDA of liver and lung was determined with fluorometry. RESULTS: The dose of 6 mg/kg Vitamin E or/and 0.8 mg/kg lipioc acid could increase the amounts of WBC and PLT in peripheral blood(P<0.05)and inhibit MDA level of liver and lung. The group Vitamin E showed best inhibition on MDA (P<0.05).The group of Vitamin E plus lipioc acid did not show significant cooperative effect;on the contrary they came forth antagonistic effect. CONCLUSION: The antioxidation effect of Vitamin E is better than lipioc acid on mice injuries caused by phosgene. Among three groups,the group of Vitamin E plus lipioc acid has certain antagonism in inhibiting the level of MDA.

Key words: phosgene, vitamin E, lipioc acid, antioxidation